A single nucleotide polymorphism in BCL-2 gene determines the risk of urinary bladder cancer
نویسنده
چکیده
The aim of the study was to investigate genetic polymorphism in apoptotic gene, BCL-2 (C938A), and the risk of bladder cancer through a hospital-based case-control study. This retrospective analysis consisted of 270 cases of bladder cancer and 252 controls. The BCL-2 938 AA genotype showed a decreased risk of bladder cancer among smokers (OR = 0.40, 95% CI = 0.19-0.85), hence, showing a protective effect. The BCL-2 938 AA genotype also showed a significant decreased risk among vegetarians (OR = 0.39, 95% CI = 0.14-1.06) for bladder cancer. No significant associations were observed for this polymorphism among any of the stages or grades of carcinoma of urinary bladder.
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